Scientific Commons: Christian Capo

Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor (2008)

Mokart, Djamel, Kipnis, Eric, Guerre-Berthelot, Pierre, Vey, Norbert, Capo, Christian, Sannini, Antoine, ...

Abstract Introduction In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have...

Persistent Coxiella burnetii Infection in Mice Overexpressing IL-10: An Efficient Model for Chronic Q Fever Pathogenesis (2008)

Soraya Meghari, Yassina Bechah, Christian Capo, Hubert Lepidi, Didier Raoult, Peter J. Murray, ...

Interleukin (IL)-10 increases host susceptibility to microorganisms and is involved in intracellular persistence of bacterial pathogens. IL-10 is associated with chronic Q fever, an infectious...

Phagocytic Function of Monocytes in Children with Human Immunodeficiency Virus Type 1 Infection

Tardei, Gratiela, Duiculescu, Dan, Capo, Christian, Diaconu, Carmen-Cristina, Mutiu, Adrian, Mege, Jean-Louis, ...

We investigated the phagocytic function of monocytes in 7- to 10-year-old children horizontally infected with human immunodeficiency virus type 1 (HIV-1) in comparison to that in healthy sex- and...

Highly Active Antiretroviral Therapy (HAART) and Circulating Markers of Immune Activation: Specific Effect of HAART on Neopterin

Amirayan-Chevillard, Nathalie, Tissot-Dupont, Herve, Obadia, Yolande, Gallais, Herve, Mege, Jean-Louis, Capo, Christian

The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected...

Increases in the Levels of Coxiella burnetii-Specific Immunoglobulin G1 and G3 Antibodies in Acute Q Fever and Chronic Q Fever

Capo, Christian, Iorgulescu, Ioana, Mutillod, Maryse, Mege, Jean-Louis, Raoult, Didier

A detailed analysis of the humoral response to Coxiella burnetii may provide insight into the pathogenesis of Q fever, a zoonosis caused by C. burnetii. The subclasses of C. burnetii-specific...

Coxiella burnetii Survives in Monocytes from Patients with Q Fever Endocarditis: Involvement of Tumor Necrosis Factor

Dellacasagrande, Jérôme, Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Endocarditis is the most frequent form of chronic Q fever, an infectious disease caused by Coxiella burnetii. As this obligate intracellular bacterium inhabits monocytes and macrophages, we wondered...

Reduced Transendothelial Migration of Monocytes Infected by Coxiella burnetii

Dellacasagrande, Jérôme, Moulin, Pierre A., Guilianelli, Catherine, Capo, Christian, Raoult, Didier, Grau, Georges E., ...

The migratory properties of THP1 monocytes infected by Coxiella burnetii were determined in a transmigration assay across a human microvascular endothelial cell monolayer. Transendothelial migration...

Interleukin-10 Stimulates Coxiella burnetii Replication in Human Monocytes through Tumor Necrosis Factor Down-Modulation: Role in Microbicidal Defect of Q Fever

Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Coxiella burnetii, an obligate intracellular bacterium, is the agent of Q fever. The chronic form of the disease is associated with the overproduction of interleukin-10 and deficient C. burnetii...

Activation of Protein Tyrosine Kinases by Coxiella burnetii: Role in Actin Cytoskeleton Reorganization and Bacterial Phagocytosis

Meconi, Sonia, Capo, Christian, Remacle-Bonnet, Maryse, Pommier, Gilbert, Raoult, Didier, Mege, Jean-Louis

Coxiella burnetii, the agent of Q fever, is an obligate intracellular microorganism that grows in monocytes/macrophages. The internalization of virulent organisms by monocytes is lower than that of...

αvβ3 Integrin and Bacterial Lipopolysaccharide Are Involved in Coxiella burnetii-Stimulated Production of Tumor Necrosis Factor by Human Monocytes

Dellacasagrande, Jérôme, Ghigo, Eric, Machergui-El , Sarah, Toman, Rudolf, Raoult, Didier, ...

Coxiella burnetii, the agent of Q fever, enters human monocytes through αvβ3 integrin and survives inside host cells. In addition, C. burnetii stimulates the synthesis of inflammatory cytokines...

Coxiella burnetii Induces Reorganization of the Actin Cytoskeleton in Human Monocytes

Meconi, Sonia, Jacomo, Véronique, Boquet, Patrice, Raoult, Didier, Mege, Jean-Louis, Capo, Christian

Coxiella burnetii, an obligate intracellular bacterium which survives in myeloid cells, causes Q fever in humans. We previously demonstrated that virulent C. burnetii organisms are poorly...

Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification

Ghigo, Eric, Capo, Christian, Aurouze, Marianne, Tung, Ching-Hsuan, Gorvel, Jean-Pierre, Raoult, Didier, ...

Tropheryma whipplei was established as the agent of Whipple's disease in 2000, but the mechanisms by which it survives within host cells are still unknown. We show here that T. whipplei survives...