HLA class I supertypes: a revised and updated classification (2008)
Sidney, John, Peters, Bjoern, Frahm, Nicole, Brander, Christian, Sette, Alessandro
Abstract Background Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of...
Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses (2007)
Frahm, Nicole, Kaufmann, Daniel E., Yusim, Karina, Muldoon, Mark, Kesmir, Can, Linde, Caitlyn H., ...
The accurate identification of HIV-specific T cell responses is important for determining the relationship between immune response, viral control, and disease progression. HIV-specific immune...
A Statistical Framework for Modeling HLA-Dependent T Cell Response Data (2007)
Jennifer Listgarten, Nicole Frahm, Carl Kadie, Christian Brander, David Heckerman
The identification of T cell epitopes and their HLA (human leukocyte antigen) restrictions is important for applications such as the design of cellular vaccines for HIV. Traditional methods for such...
Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...
Zabrina L. Brumme, Chanson J. Brumme, David Heckerman, Bette T. Korber, Marcus Daniels, Jonathan Carlson, ...
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...
Transfusion-transmitted infections (2007)
Bihl, Florian, Castelli, Damiano, Marincola, Francesco, Dodd, Roger Y, Brander, Christian
Abstract Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human...
Olivier Gasser, Florian K. Bihl, Marcel Wolbers, Elisabetta Loggi, Ingrid Steffen, Hans H. Hirsch, ...
BackgroundIn chronic HIV infection, antiretroviral therapy–induced normalization of CD4+ T cell counts (immune reconstitution [IR]) is associated with a decreased incidence of opportunistic...
Rewarding patient-directed research: Excellence in Translational Medicine Award (2006)
Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
Abstract The Editorial Board of Journal of Translational Medicine is pleased to announce a prize to recognize outstanding contributions in the field of translational medicine. The prize is sponsored...
Bihl, Florian K, Loggi, Elisabetta, Chisholm, John V, Hewitt, Hannah S, Henry, Leah M, Linde, Caitlyn, ...
Abstract The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T...
Lost in Translation: Obstacles to Translational Medicine (2004)
Mankoff, Stacey P, Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
Abstract When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM ,...
Addo, Marylyn M., Altfeld, Marcus, Rosenberg, Eric S., Eldridge, Robert L., Philips, Mary N., Habeeb, Kathleen, ...
The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However,...
Brander, Christian, Yang, Otto O., Jones, Norman G., Lee, Yun, Goulder, Philip, Johnson, R. Paul, ...
Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with...
Altfeld, Marcus A., Livingston, Brian, Reshamwala, Neha, Nguyen, Phuong T., Addo, Marylyn M., Shea, Amy, ...
Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and...
Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4+ T-Cell Clones
Norris, Philip J., Sumaroka, Marina, Brander, Christian, Moffett, Howell F., Boswell, Steven L., Nguyen, Tam, ...
Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise...
Altfeld, Marcus, Addo, Marylyn M., Shankarappa, Raj, Lee, Paul K., Allen, Todd M., Yu, Xu G., ...
The antigenic diversity of human immunodeficiency virus type 1 (HIV-1) represents a significant challenge for vaccine design as well as the comprehensive assessment of HIV-1-specific immune responses...
Kaufmann, Daniel E., Bailey, Paul M., Sidney, John, Wagner, Bradford, Norris, Philip J., Johnston, Mary N., ...
Increasing evidence suggests that human immunodeficiency virus type 1 (HIV-1)-specific CD4 T-cell responses contribute to effective immune control of HIV-1 infection. However, the breadths and...
Lost in Translation: Obstacles to Translational Medicine
Mankoff, Stacey P, Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM, we have...
Allen, Todd M., Altfeld, Marcus, Yu, Xu G., O'Sullivan, Kristin M., Lichterfeld, Mathias, Le Gall, Sylvie, ...
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA...
Altfeld, Marcus, Allen, Todd M., Kalife, Elizabeth T., Frahm, Nicole, Addo, Marylyn M., Mothe, Bianca R., ...
Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons...
Bihl, Florian K, Loggi, Elisabetta, Chisholm, John V, Hewitt, Hannah S, Henry, Leah M, Linde, Caitlyn, ...
The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell...
Frahm, Nicole, Adams, Sharon, Kiepiela, Photini, Linde, Caitlyn H., Hewitt, Hannah S., Lichterfeld, Mathias, ...
Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL)...
Allen, Todd M., Yu, Xu G., Kalife, Elizabeth T., Reyor, Laura L., Lichterfeld, Mathias, John, Mina, ...
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell...
Allen, Todd M., Altfeld, Marcus, Geer, Shaun C., Kalife, Elizabeth T., Moore, Corey, O'Sullivan, Kristin M., ...
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen...
Rewarding patient-directed research: Excellence in Translational Medicine Award
Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
The Editorial Board of Journal of Translational Medicine is pleased to announce a prize to recognize outstanding contributions in the field of translational medicine. The prize is sponsored by Pfizer...
Zuñiga, Rosario, Lucchetti, Aldo, Galvan, Patricia, Sanchez, Shyla, Sanchez, Carmen, Hernandez, Ana, ...
Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present...
Martinez-Picado, Javier, Prado, Julia G., Fry, Elizabeth E., Pfafferott, Katja, Leslie, Alasdair, Chetty, Senica, ...
Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may...
Addo, Marylyn M., Altfeld, Marcus, Rosenberg, Eric S., Eldridge, Robert L., Philips, Mary N., Habeeb, Kathleen, ...
The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However,...
Brander, Christian, Yang, Otto O., Jones, Norman G., Lee, Yun, Goulder, Philip, Johnson, R. Paul, ...
Immune escape from cytotoxic T-lymphocyte (CTL) responses has been shown to occur not only by changes within the targeted epitope but also by changes in the flanking sequences which interfere with...
Altfeld, Marcus A., Livingston, Brian, Reshamwala, Neha, Nguyen, Phuong T., Addo, Marylyn M., Shea, Amy, ...
Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and...
Multiple Effector Functions Mediated by Human Immunodeficiency Virus-Specific CD4+ T-Cell Clones
Norris, Philip J., Sumaroka, Marina, Brander, Christian, Moffett, Howell F., Boswell, Steven L., Nguyen, Tam, ...
Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise...
Altfeld, Marcus, Addo, Marylyn M., Shankarappa, Raj, Lee, Paul K., Allen, Todd M., Yu, Xu G., ...
The antigenic diversity of human immunodeficiency virus type 1 (HIV-1) represents a significant challenge for vaccine design as well as the comprehensive assessment of HIV-1-specific immune responses...
Kaufmann, Daniel E., Bailey, Paul M., Sidney, John, Wagner, Bradford, Norris, Philip J., Johnston, Mary N., ...
Increasing evidence suggests that human immunodeficiency virus type 1 (HIV-1)-specific CD4 T-cell responses contribute to effective immune control of HIV-1 infection. However, the breadths and...
Lost in Translation: Obstacles to Translational Medicine
Mankoff, Stacey P, Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
When we launched the Journal of Translational Medicine a few months ago, we were interested primarily in exploring scientific consideration of this discipline. However, as editors of JTM, we have...
Allen, Todd M., Altfeld, Marcus, Yu, Xu G., O'Sullivan, Kristin M., Lichterfeld, Mathias, Le Gall, Sylvie, ...
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA...
Altfeld, Marcus, Allen, Todd M., Kalife, Elizabeth T., Frahm, Nicole, Addo, Marylyn M., Mothe, Bianca R., ...
Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons...
Bihl, Florian K, Loggi, Elisabetta, Chisholm, John V, Hewitt, Hannah S, Henry, Leah M, Linde, Caitlyn, ...
The assessment of cellular anti-viral immunity is often hampered by the limited availability of adequate samples, especially when attempting simultaneous, high-resolution determination of T cell...
Frahm, Nicole, Adams, Sharon, Kiepiela, Photini, Linde, Caitlyn H., Hewitt, Hannah S., Lichterfeld, Mathias, ...
Several HLA class I alleles have been associated with slow human immunodeficiency virus (HIV) disease progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL)...
Allen, Todd M., Yu, Xu G., Kalife, Elizabeth T., Reyor, Laura L., Lichterfeld, Mathias, John, Mina, ...
Human immunodeficiency virus type 1 (HIV-1) evades CD8+ T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8+ T-cell...
Allen, Todd M., Altfeld, Marcus, Geer, Shaun C., Kalife, Elizabeth T., Moore, Corey, O'Sullivan, Kristin M., ...
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen...
Zuñiga, Rosario, Lucchetti, Aldo, Galvan, Patricia, Sanchez, Shyla, Sanchez, Carmen, Hernandez, Ana, ...
Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in the control of human immunodeficiency virus (HIV) disease progression exist. We present...
Martinez-Picado, Javier, Prado, Julia G., Fry, Elizabeth E., Pfafferott, Katja, Leslie, Alasdair, Chetty, Senica, ...
Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may...
Rewarding patient-directed research: Excellence in Translational Medicine Award
Brander, Christian, Ferrone, Soldano, Marincola, Francesco M
The Editorial Board of Journal of Translational Medicine is pleased to announce a prize to recognize outstanding contributions in the field of translational medicine. The prize is sponsored by Pfizer...
Gasser, Olivier, Bihl, Florian K, Wolbers, Marcel, Loggi, Elisabetta, Steffen, Ingrid, Hirsch, Hans H, ...
In a case-control study from the Swiss HIV cohort, Hess and colleagues report that T-helper responses against Epstein-Barr virus are specifically absent in patients developing CNS lymphoma.
Yu, Xu G., Lichterfeld, Mathias, Chetty, Senica, Williams, Katie L., Mui, Stanley K., Miura, Toshiyuki, ...
The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific...
The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
Islam, Sabina A., Thomas, Seddon Y., Hess, Christoph, Medoff, Benjamin D., Means, Terry K., Brander, Christian, ...
We have recently shown that the leukotriene B4 (LTB4)–BLT1 pathway is important in early effector T-cell recruitment in mouse models of inflammation. Here we characterize the phenotype and function...
Kavanagh, Daniel G., Kaufmann, Daniel E., Sunderji, Sherzana, Frahm, Nicole, Le Gall, Sylvie, Boczkowski, David, ...
Transfection with synthetic mRNA is a safe and efficient method of delivering antigens to dendritic cells for immunotherapy. Targeting antigens to the lysosome can sometimes enhance the CD4+ T-cell...
Transfusion-transmitted infections
Bihl, Florian, Castelli, Damiano, Marincola, Francesco, Dodd, Roger Y, Brander, Christian
Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human...
Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational...
Honeyborne, Isobella, Prendergast, Andrew, Pereyra, Florencia, Leslie, Alasdair, Crawford, Hayley, Payne, Rebecca, ...
To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with...
Brumme, Zabrina L, Brumme, Chanson J, Heckerman, David, Korber, Bette T, Daniels, Marcus, Carlson, Jonathan, ...
Rousseau, Christine M., Learn, Gerald H., Bhattacharya, Tanmoy, Nickle, David C., Heckerman, David, Chetty, Senica, ...
Recombinant human immunodeficiency virus type 1 (HIV-1) strains containing sequences from different viral genetic subtypes (intersubtype) and different lineages from within the same subtype...
Bihl, Florian, Narayan, Murli, Chisholm, John V., Henry, Leah M., Suscovich, Todd J., Brown, Elizabeth E., ...
The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and...
Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins
Rolland, Morgane, Nickle, David C., Deng, Wenjie, Frahm, Nicole, Brander, Christian, Learn, Gerald H., ...
A Statistical Framework for Modeling HLA-Dependent T Cell Response Data
Listgarten, Jennifer, Frahm, Nicole, Kadie, Carl, Brander, Christian, Heckerman, David
The identification of T cell epitopes and their HLA (human leukocyte antigen) restrictions is important for applications such as the design of cellular vaccines for HIV. Traditional methods for such...
Nef interference with HIV-1–specific CTL antiviral activity is epitope specific
Adnan, Sama, Balamurugan, Arumugam, Trocha, Alicja, Bennett, Michael S., Ng, Hwee L., Ali, Ayub, ...
HIV-1 Nef and HIV-1–specific cytotoxic T lymphocytes (CTLs) have important and opposing roles in the immunopathogenesis of HIV-1 infection. Nef-mediated down-modulation of HLA class I on infected...
Crawford, Hayley, Prado, Julia G., Leslie, Alasdair, Hué, Stéphane, Honeyborne, Isobella, Reddy, Sharon, ...
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted...