Koyano-Nakagawa, Naoko, Kim, Jaesang, Anderson, David, Kintner, Chris
During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal...
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Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
Fryer, Christy J., Lamar, Elise, Turbachova, Ivana, Kintner, Chris, Jones, Katherine A.
Signaling through the Notch pathway activates the proteolytic release of the Notch intracellular domain (ICD), a dedicated transcriptional coactivator of CSL enhancer-binding proteins. Here we show...
Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-α homolog Spitz
Activation of the Drosophila epidermal growth factor receptor (DER) by the transmembrane ligand, Spitz (Spi), requires two additional transmembrane proteins, Rhomboid and Star. Genetic evidence...
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
Jen, Wui-Chuong, Gawantka, Volker, Pollet, Nicolas, Niehrs, Christof, Kintner, Chris
During the development of the vertebrate embryo, genes encoding components of the Notch signaling pathway are required for subdividing the paraxial mesoderm into repeating segmental structures,...
Liu, Jun, Bang, Anne G., Kintner, Chris, Orth, Anthony P., Chanda, Sumit K., Ding, Sheng, ...
The Wnt signaling pathway acts ubiquitously in metazoans to control various aspects of embryonic development. Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor-related...
Nrarp is a novel intracellular component of the Notch signaling pathway
Lamar, Elise, Deblandre, Gisèle, Wettstein, Daniel, Gawantka, Volker, Pollet, Nicolas, Niehrs, Christof, ...
The Lin12/Notch receptors regulate cell fate during embryogenesis by activating the expression of downstream target genes. These receptors signal via their intracellular domain (ICD), which is...
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
Fryer, Christy J., Lamar, Elise, Turbachova, Ivana, Kintner, Chris, Jones, Katherine A.
Signaling through the Notch pathway activates the proteolytic release of the Notch intracellular domain (ICD), a dedicated transcriptional coactivator of CSL enhancer-binding proteins. Here we show...
Nrarp is a novel intracellular component of the Notch signaling pathway
Lamar, Elise, Deblandre, Gisèle, Wettstein, Daniel, Gawantka, Volker, Pollet, Nicolas, Niehrs, Christof, ...
The Lin12/Notch receptors regulate cell fate during embryogenesis by activating the expression of downstream target genes. These receptors signal via their intracellular domain (ICD), which is...
Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-α homolog Spitz
Activation of the Drosophila epidermal growth factor receptor (DER) by the transmembrane ligand, Spitz (Spi), requires two additional transmembrane proteins, Rhomboid and Star. Genetic evidence...
Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
Jen, Wui-Chuong, Gawantka, Volker, Pollet, Nicolas, Niehrs, Christof, Kintner, Chris
During the development of the vertebrate embryo, genes encoding components of the Notch signaling pathway are required for subdividing the paraxial mesoderm into repeating segmental structures,...
Liu, Jun, Bang, Anne G., Kintner, Chris, Orth, Anthony P., Chanda, Sumit K., Ding, Sheng, ...
The Wnt signaling pathway acts ubiquitously in metazoans to control various aspects of embryonic development. Wnt ligands bind their receptors Frizzled and low-density lipoprotein receptor-related...
Ladi, Ena, Nichols, James T., Ge, Weihong, Miyamoto, Alison, Yao, Christine, Yang, Liang-Tung, ...
Mutations in the DSL (Delta, Serrate, Lag2) Notch (N) ligand Delta-like (Dll) 3 cause skeletal abnormalities in spondylocostal dysostosis, which is consistent with a critical role for N signaling...