Chin Lin

Tireoidectomia total para bócio multinodular (2003)

Friguglietti,Celso U.M., Lin,Chin, Kulcsar,Marco A.V.

INTRODUÇÃO: Preservar tecido tireóideo em cirurgias para bócio multinodular (BM) não evita a complementação hormonal e pode gerar recidiva. A reoperação aumenta em até 20 vezes o risco de...

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb βs-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, ...

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional...

Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus

Gaensler, Karin M. L., Zhang, Zemin, Lin, Chin, Yang, Suya, Hardt, Karin, Flebbe-Rehwaldt, Linda

The human β-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including...

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb βs-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, ...

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional...

Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus

Gaensler, Karin M. L., Zhang, Zemin, Lin, Chin, Yang, Suya, Hardt, Karin, Flebbe-Rehwaldt, Linda

The human β-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including...

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context

Rodríguez, Fabián A., Cai, Yuqin, Lin, Chin, Tang, Yijin, Kolbanovskiy, Alexander, Amin, Shantu, ...

The environmental carcinogen benzo[a]pyrene (BP) is metabolized to reactive diol epoxides that bind to cellular DNA by predominantly forming N2-guanine adducts (G*). Mutation hotspots for these...

Fetal gene therapy of α-thalassemia in a mouse model

Han, Xiao-Dong, Lin, Chin, Chang, Judy, Sadelain, Michel, Kan, Y. W.

Fetuses with homozygous α-thalassemia usually die at the third trimester of pregnancy or soon after birth. Hence, the disease could potentially be a target for fetal gene therapy. We have previously...

A network flow approach to optimizing hospital bed capacity decisions

Elif Akcali, Murray Côté, Chin Lin

The delivery of cost-effective and quality hospital-based health care remains an important and ongoing challenge for the American health care industry. Despite numerous advances in medical procedures...