Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously (2006)
Lamoureux, Jennifer L, Buckner, Jane, David, Chella S, Bradley, David S
Abstract Relapsing polychondritis (RP) is a human autoimmune disease of unknown etiology in which cartilaginous sites are destroyed by cyclic inflammatory episodes beginning, most commonly, during...
Taneja, Veena, David, Chella S
Abstract Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked...
Carra, John H., Welcher, Brent C., Schokman, Rowene D., David, Chella S., Bavari, Sina
The influence of mutationally induced changes in protein folding on development of effective neutralizing antibodies during vaccination remains largely unexplored. In this study, we probed how...
Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...
Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...
The H-2 haplotype of the PN (Palmerston North) inbred strain (1982)
Walker, Sara Ellen, David, Chella S., Schultz, Jane S.
Peer Reviewed
David, Chella S., Shreffler, Donald C., Stimpfling, Jack H.
Specificity H-2.7 is expressed predominantly on erythrocytes and controlled by a gene that maps within the H-2 gene complex at a locus, designated as H-2G , which apparently lies between regions S...
Götze, Dietrich, Timpl, Rupert, Nowack, Hans, Hahn, Eckhart, David, Chella S.
The genetically controlled immune response to calf skin collagen type I in mice could be demonstrated to be governed by at least two genes. One is linked to the H-2 complex and located within the IA...
The specificity and significance of the inhibition of Fc receptor binding by anti H-2 sera (1975)
David, Chella S., Schirrmacher, Volker, Halloran, Phil
The possibility that Ia antigens are unique among H-2 antigens in their relationship to the Fc receptor was investigated in an EA rosette assay. Antibody specific for antigens in various regions of...
Götze, Dietrich, David, Chella S., McDevitf, H., Klein, Jan, Sachs, D., Shreffler, Donald C.
Peer Reviewed
Gamma globulin allotypes in the fowl /--by Chelladurai Shantaseelan David. (1966)
Typescript (photocopy)
Geluk, Annemieke, Taneja, Veena, Van Meijgaarden, Krista E., Zanelli, Eric, Abou-Zeid, Christiane, Thole, Jelle E. R., ...
T helper 1 cells play a major role in protective immunity against mycobacterial pathogens. Since the antigen (Ag) specificity of CD4+ human T cells is strongly controlled by HLA class II...
Pimtanothai, Nattiya, Parra, Marcela, Johnson, Armead H., David, Chella S., Katovich Hurley, Carolyn
A subunit vaccine for Plasmodium falciparum malaria will need to contain well-defined T helper cell epitopes that induce protective immune responses to the parasite. One major barrier to the use of...
Differential Effects of Infection with a Babesia-Like Piroplasm, WA1, in Inbred Mice
Moro, Manuel H., David, Chella S., Magera, Jenifer M., Wettstein, Peter J., Barthold, Stephen W., Persing, David H.
A newly identified intraerythrocytic Babesia-like organism, WA1, and its relatives were recently shown to be infectious for humans in the western United States. The purpose of the present study was...
Taneja, Veena, David, Chella S
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous...
Lin, Xiaoqi, Njenga, M. Kariuki, Johnson, Aaron J., Pavelko, Kevin D., David, Chella S., Pease, Larry R., ...
We investigated the role of the immune system in protecting against virus-induced demyelination by generating lines of transgenic B10 (H-2b) congenic mice expressing three independent contiguous...
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
Pennesi, Giuseppina, Mattapallil, Mary J., Sun, Shu-Hui, Avichezer, Dody, Silver, Phyllis B., Karabekian, Zaruhi, ...
Experimental autoimmune uveitis (EAU) is a disease of the neural retina induced by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein (IRBP) and arrestin (retinal...
Taneja, Veena, Griffiths, Marie, Behrens, Marshall, Luthra, Harvinder S., David, Chella S.
Relapsing polychondritis is a multisystem autoimmune disease involving cartilage destruction but no known causative antigen. HLA-DQ8 has been associated with various autoimmune diseases in humans. To...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice
Chapoval, Svetlana P., Nabozny, Gerald H., Marietta, Eric V., Raymond, Ernie L., Krco, Christopher J., Andrews, Amy G., ...
The human leukocyte antigen (HLA) restriction of the IgE response to different allergens in humans has been a subject of numerous published studies. However, the role and contribution of specific HLA...
Unanue, Emil R., Dorf, Martin E., David, Chella S., Benacerraf, Baruj
The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The...
In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists
Rajagopalan, Govindarajan, Sen, Moon M., David, Chella S.
Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They...
Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...
Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...
Endogenous Superantigens Shape Response to Exogenous Superantigens
Rajagopalan, Govindarajan, Singh, Manisha, Sen, Moon M., Murali, Narayana S., Nath, Karl A., David, Chella S.
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response...
Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice.
Chapoval, Svetlana P, David, Chella S
Environmental factors play an important role in the rise and manifestation of allergic conditions in genetically predisposed subjects. Increased exposure to indoor/outdoor allergens is a significant...
Rajagopalan, Govindarajan, Iijima, Koji, Singh, Manisha, Kita, Hirohito, Patel, Robin, David, Chella S.
Staphylococcus aureus is widely prevalent in the nasopharynges of healthy individuals (carriers) but can also cause serious infections. S. aureus can elaborate a variety of superantigen exotoxins in...
Geluk, Annemieke, Taneja, Veena, Van Meijgaarden, Krista E., Zanelli, Eric, Abou-Zeid, Christiane, Thole, Jelle E. R., ...
T helper 1 cells play a major role in protective immunity against mycobacterial pathogens. Since the antigen (Ag) specificity of CD4+ human T cells is strongly controlled by HLA class II...
Pimtanothai, Nattiya, Parra, Marcela, Johnson, Armead H., David, Chella S., Katovich Hurley, Carolyn
A subunit vaccine for Plasmodium falciparum malaria will need to contain well-defined T helper cell epitopes that induce protective immune responses to the parasite. One major barrier to the use of...
Differential Effects of Infection with a Babesia-Like Piroplasm, WA1, in Inbred Mice
Moro, Manuel H., David, Chella S., Magera, Jenifer M., Wettstein, Peter J., Barthold, Stephen W., Persing, David H.
A newly identified intraerythrocytic Babesia-like organism, WA1, and its relatives were recently shown to be infectious for humans in the western United States. The purpose of the present study was...
Taneja, Veena, David, Chella S
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous...
Lin, Xiaoqi, Njenga, M. Kariuki, Johnson, Aaron J., Pavelko, Kevin D., David, Chella S., Pease, Larry R., ...
We investigated the role of the immune system in protecting against virus-induced demyelination by generating lines of transgenic B10 (H-2b) congenic mice expressing three independent contiguous...
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
Pennesi, Giuseppina, Mattapallil, Mary J., Sun, Shu-Hui, Avichezer, Dody, Silver, Phyllis B., Karabekian, Zaruhi, ...
Experimental autoimmune uveitis (EAU) is a disease of the neural retina induced by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein (IRBP) and arrestin (retinal...
Taneja, Veena, Griffiths, Marie, Behrens, Marshall, Luthra, Harvinder S., David, Chella S.
Relapsing polychondritis is a multisystem autoimmune disease involving cartilage destruction but no known causative antigen. HLA-DQ8 has been associated with various autoimmune diseases in humans. To...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice
Chapoval, Svetlana P., Nabozny, Gerald H., Marietta, Eric V., Raymond, Ernie L., Krco, Christopher J., Andrews, Amy G., ...
The human leukocyte antigen (HLA) restriction of the IgE response to different allergens in humans has been a subject of numerous published studies. However, the role and contribution of specific HLA...
Unanue, Emil R., Dorf, Martin E., David, Chella S., Benacerraf, Baruj
The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The...
In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists
Rajagopalan, Govindarajan, Sen, Moon M., David, Chella S.
Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They...
Roy, Chad J., Warfield, Kelly L., Welcher, Brent C., Gonzales, Raoul F., Larsen, Tom, Hanson, Julie, ...
Staphylococcal enterotoxins (SEs) belong to a large group of bacterial exotoxins that cause severe immunopathologies, especially when delivered as an aerosol. SEs elicit the release of lethal amounts...
Endogenous Superantigens Shape Response to Exogenous Superantigens
Rajagopalan, Govindarajan, Singh, Manisha, Sen, Moon M., Murali, Narayana S., Nath, Karl A., David, Chella S.
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response...
Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice.
Chapoval, Svetlana P, David, Chella S
Environmental factors play an important role in the rise and manifestation of allergic conditions in genetically predisposed subjects. Increased exposure to indoor/outdoor allergens is a significant...
Rajagopalan, Govindarajan, Iijima, Koji, Singh, Manisha, Kita, Hirohito, Patel, Robin, David, Chella S.
Staphylococcus aureus is widely prevalent in the nasopharynges of healthy individuals (carriers) but can also cause serious infections. S. aureus can elaborate a variety of superantigen exotoxins in...
Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously
Lamoureux, Jennifer L, Buckner, Jane Hoyt, David, Chella S, Bradley, David S
Relapsing polychondritis (RP) is a human autoimmune disease of unknown etiology in which cartilaginous sites are destroyed by cyclic inflammatory episodes beginning, most commonly, during the fourth...
Acute Systemic Immune Activation following Conjunctival Exposure to Staphylococcal Enterotoxin B
Rajagopalan, Govindarajan, Smart, Michele K., Patel, Robin, David, Chella S.
Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the...
Pavelko, Kevin D, Pease, Larry R, David, Chella S, Rodriguez, Moses
An important question in neuropathology involves determining the antigens that are targeted during demyelinating disease. Viral infection of the central nervous system (CNS) leads to T-cell responses...
Flynn, Jeffrey C, Gilbert, Jacqueline A, Meroueh, Chady, Snower, Daniel P, David, Chella S, Kong, Yi-chi M, ...
We have examined the induction of autoimmunity and the maintenance of sustained hyperthyroidism in autoimmunity-prone human leucocyte antigen (HLA) DR3 transgenic non-obese diabetic (NOD) mice...