Chang Z. Zhu

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Jarvis, Michael F., Burgard, Edward C., McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J., ...

P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP....

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

Jarvis, Michael F., Burgard, Edward C., McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J., ...

P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP....

Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

McGaraughty, Steve, Wismer, Carol T, Zhu, Chang Z, Mikusa, Joseph, Honore, Prisca, Chu, Katharine L, ...

We have recently reported that systemic delivery of A-317491, the first non-nucleotide antagonist that has high affinity and selectivity for blocking P2X3 homomeric and P2X2/3 heteromeric channels,...

Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain

McGaraughty, Steve, Honore, Prisca, Wismer, Carol T, Mikusa, Joseph, Zhu, Chang Z, McDonald, Heath A, ...

P2X3/P2X2/3 receptors have emerged as important components of nociception. However, there is limited information regarding the neurochemical systems that are affected by antagonism of the P2X3/P2X2/3...