Cemile Jakupoglu

Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen (2003)

Jakupoglu, Cemile

Thioredoxin Reductases (TR) are ubiquitously expressed Selenium-containing redox enzymes. By reducing different intracellular substrates they protect cells from oxidative stress. For mus musculus two...

Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen (2003)

Jakupoglu, Cemile

Thioredoxin Reductases (TR) are ubiquitously expressed Selenium-containing redox enzymes. By reducing different intracellular substrates they protect cells from oxidative stress. For mus musculus two...

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, Marcus, Jakupoglu, Cemile, Moreno, Stéphanie G., Lippl, Stefanie, Banjac, Ana, Schneider, Manuela, ...

Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two...

Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development

Jakupoglu, Cemile, Przemeck, Gerhard K. H., Schneider, Manuela, Moreno, Stéphanie G., Mayr, Nadja, Hatzopoulos, Antonis K., ...

Two distinct thioredoxin/thioredoxin reductase systems are present in the cytosol and the mitochondria of mammalian cells. Thioredoxins (Txn), the main substrates of thioredoxin reductases (Txnrd),...

Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

Conrad, Marcus, Jakupoglu, Cemile, Moreno, Stéphanie G., Lippl, Stefanie, Banjac, Ana, Schneider, Manuela, ...

Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two...

Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development

Jakupoglu, Cemile, Przemeck, Gerhard K. H., Schneider, Manuela, Moreno, Stéphanie G., Mayr, Nadja, Hatzopoulos, Antonis K., ...

Two distinct thioredoxin/thioredoxin reductase systems are present in the cytosol and the mitochondria of mammalian cells. Thioredoxins (Txn), the main substrates of thioredoxin reductases (Txnrd),...

Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI11

Piepoli, Tiziana, Jakupoglu, Cemile, Gu, Wenli, Lualdi, Elena, Suarez-Merino, Blanca, Poliani, Pietro L., ...

Disruptions of LGI1 in glioblastoma (GBM) cell lines and LGI1 mutations in families with autosomal dominant epilepsy imply a role for LGI1 in glial cells as well as in neurons. Although we and others...

The Role of Thioredoxin Reductases in Brain Development

Soerensen, Jonna, Jakupoglu, Cemile, Beck, Heike, Förster, Heidi, Schmidt, Jörg, Schmahl, Wolfgang, ...

The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we studied the roles of thioredoxin...