Catherine de Lara

Clustered DNA damage induced by γ radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites

Gulston, Melanie, Fulford, Jonathan, Jenner, Terry, De Lara, Catherine, O’Neill, Peter

The signature DNA lesion induced by ionizing radiation is clustered DNA damage. Gamma radiation-induced clustered DNA damage containing base lesions was investigated in plasmid DNA under cell mimetic...

Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation

Gulston, Melanie, De Lara, Catherine, Jenner, Terry, Davis, Emma, O'Neill, Peter

Clustered DNA damage sites, in which two or more lesions are formed within a few helical turns of the DNA after passage of a single radiation track, are signatures of DNA modifications induced by...

Clustered DNA damage induced by γ radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites

Gulston, Melanie, Fulford, Jonathan, Jenner, Terry, De Lara, Catherine, O’Neill, Peter

The signature DNA lesion induced by ionizing radiation is clustered DNA damage. Gamma radiation-induced clustered DNA damage containing base lesions was investigated in plasmid DNA under cell mimetic...

Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation

Gulston, Melanie, De Lara, Catherine, Jenner, Terry, Davis, Emma, O'Neill, Peter

Clustered DNA damage sites, in which two or more lesions are formed within a few helical turns of the DNA after passage of a single radiation track, are signatures of DNA modifications induced by...

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, Derek C., Wallace, Diana, Zhang, Yan, De Lara, Catherine, Worth, Andrew T., Ghattas, Hala, ...

Memory T cells can be divided into central–memory (TCM) and effector–memory (TEM) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not...