Byeong Jae Lee

Specific Excision of the Selenocysteine tRNA [Ser]Sec (Trsp) Gene in Mouse Liver Demonstrates an Essential Role of Selenoproteins in Liver Function (2004)

Carlson, Bradley A., Novoselov, Sergey V., Kumaraswamy, Easwari, Jae Lee, Byeong, Anver, Miriam R., Gladyshev, Vadim N., ...

Selenium is essential in mammalian embryonic development. However, in adults, selenoprotein levels in several organs including liver can be substantially reduced by selenium deficiency without any...

The Drosophila Selenoprotein BthD Is Required for Survival and Has a Role in Salivary Gland Development (2003)

Kwon, So Yeon, Badenhorst, Paul, Martin-Romero, F. Javier, Carlson, Bradley A., Paterson, Bruce M., Gladyshev, Vadim, ...

Selenium is implicated in many diseases, including cancer, but its function at the molecular level is poorly understood. BthD is one of three selenoproteins recently identified in Drosophila. To...

Selective Removal of the Selenocysteine tRNA [Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium (2003)

Kumaraswamy, Easwari, Carlson, Bradley A., Morgan, Fanta, Miyoshi, Keiko, Robinson, Gertraud W., Su, Dan, ...

Mice homozygous for an allele encoding the selenocysteine (Sec) tRNA [Ser]Sec gene (Trsp) flanked by loxP sites were generated. Cre recombinase-dependent removal of Trsp in these mice was lethal to...

Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA (2001)

Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammed A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., ...

Selenocysteine (Sec) tRNA (tRNA [Ser]Sec) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein...

Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases (1999)

Sun, Qi-An, Wu, Yalin, Zappacosta, Francesca, Jeang, Kuan-Teh, Jae Lee, Byeong, Hatfield, Dolph L., ...

The intracellular generation of reactive oxygen species, together with the thioredoxin and glutathione systems, is thought to participate in redox signaling in mammalian cells. The activity of...

The Drosophila Selenoprotein BthD Is Required for Survival and Has a Role in Salivary Gland Development

Kwon, So Yeon, Badenhorst, Paul, Martin-Romero, F. Javier, Carlson, Bradley A., Paterson, Bruce M., Gladyshev, Vadim N., ...

Selenium is implicated in many diseases, including cancer, but its function at the molecular level is poorly understood. BthD is one of three selenoproteins recently identified in Drosophila. To...

The Drosophila Selenoprotein BthD Is Required for Survival and Has a Role in Salivary Gland Development

Kwon, So Yeon, Badenhorst, Paul, Martin-Romero, F. Javier, Carlson, Bradley A., Paterson, Bruce M., Gladyshev, Vadim N., ...

Selenium is implicated in many diseases, including cancer, but its function at the molecular level is poorly understood. BthD is one of three selenoproteins recently identified in Drosophila. To...