Li, Hongzhe, Rajendran, Grace K, Liu, Ninning, Ware, Carol, Rubin, Brian P, Gu, Yansong
Abstract Introduction Estrogen and insulin-like growth factor-1 (IGF-1) play important roles in mammary gland development and breast cancer. SirT1 is a highly conserved protein deacetylase that can...
Determination of Stromal Signatures in Breast Carcinoma (2005)
Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...
The authors used two different fibroblastic tumors to identify markers expressed by normal stroma cells (the supporting framework of body tissues and/or tumors), and show that different stromal...
Determination of Stromal Signatures in Breast Carcinoma (2005)
Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
Determination of Stromal Signatures in Breast Carcinoma
West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma
Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...
West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....
Determination of Stromal Signatures in Breast Carcinoma
West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....
Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma
Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...
West, Robert B., Corless, Christopher L., Chen, Xin, Rubin, Brian P., Subramanian, Subbaya, Montgomery, Kelli, ...
We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a...
KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors
Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, ...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor tyrosine kinase, and many cases have activating...
Human cancers express a mutator phenotype
Bielas, Jason H., Loeb, Keith R., Rubin, Brian P., True, Lawrence D., Loeb, Lawrence A.
Cancer cells contain numerous clonal mutations, i.e., mutations that are present in most or all malignant cells of a tumor and have presumably been selected because they confer a proliferative...
Rubin, Brian P., Chen, Chang-Jie, Morgan, Thomas W., Xiao, Sheng, Grier, Holcombe E., Kozakewich, Harry P., ...
Morphological, cytogenetic, and biological evidence supports a relationship between congenital (infantile) fibrosarcoma (CFS) and congenital mesoblastic nephroma (CMN). These tumors have a very...
TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors
Lawrence, Brandon, Perez-Atayde, Antonio, Hibbard, Michele K., Rubin, Brian P., Dal Cin, Paola, Pinkus, Jack L., ...
Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate composed primarily of lymphocytes and plasma cells. The myofibroblastic cells...
KIT Gene Mutations in Gastrointestinal Stromal Tumors : More Complex than Previously Recognized?
Fletcher, Jonathan A., Fletcher, Christopher D.M., Rubin, Brian P., Ashman, Leonie K., Corless, Christopher L., Heinrich, Michael C.
Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans
Linn, Sabine C., West, Rob B., Pollack, Jonathan R., Zhu, Shirley, Hernandez-Boussard, Tina, Nielsen, Torsten O., ...
Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFβ genes. We determined...
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
Thomas, David M., Johnson, Sandra A., Sims, Natalie A., Trivett, Melanie K., Slavin, John L., Rubin, Brian P., ...
The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt...