Aniruddha Sengupta

Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism (2008)

Sengupta, Aniruddha, Carlson, Bradley A., Hoffmann, Victoria J., Gladyshev, Vadim N., Hatfield, Dolph L.

Selenium is incorporated into proteins as selenocysteine (Sec), which is dependent on its specific tRNA, designated tRNA [Ser]Sec. Targeted removal of the tRNA [Ser]Sec gene (Trsp) in mouse...

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life (2007)

Lobanov, Alexey V., Fomenko, Dmitri E., Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L., Gladyshev, Vadim N.

Background: Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and...

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life (2007)

Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N

Abstract Background Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both...

SELECTIVE RESTORATION OF THE SELENOPROTEIN POPULATION IN A MOUSE HEPATOCYTE SELENOPROTEINLESS BACKGROUND WITH DIFFERENT MUTANT SELENOCYSTEINE tRNAs LACKING (2007)

Carlson, Bradley A., Moustafa, Mohamed E., Sengupta, Aniruddha, Schweizer, Ulrich, Shrimali, Rajeev, Rao, Mahadev, ...

Novel mouse models were developed in which the hepatic selenoprotein population was targeted for removal by disrupting the selenocysteine (Sec) tRNA [Ser]Sec gene (trsp) and then selenoprotein...

Mouse models for assessing the role of selenoproteins in health and development (2006)

Carlson, Bradley A., Xu, Xue-Ming, Shrimali, Rajeev, Sengupta, Aniruddha, Yoo, Min-Hyuk, Zhong, Nianxin, ...

Mouse models have been generated to assess the roles of selenoproteins involved with housekeeping tasks and/or stress-related phenomena in development and health. Each mouse model has taken advantage...

Mammalian and other eukaryotic selenocysteine tRNAs (2006)

Carlson, Bradley A., Xu, Xue-Ming, Shrimali, Rajeev, Sengupta, Aniruddha, Yoo, Min-Hyuk, Irons, Robert, ...

Selenocysteine (Sec) tRNA occupies a prominent position in the expression of selenoproteins as it is essential for their synthesis and it provides the means by which selenium is co-translationally...

Truncated variants of hyaluronan-binding protein 1 bind hyaluronan and induce identical morphological aberrations in COS-1 cells.

Sengupta, Aniruddha, Tyagi, Rakesh K, Datta, Kasturi

Hyaluronan (HA)-binding protein 1 (HABP1) is multifunctional in nature and exists as a trimer through coiled-coil interaction between alpha-helices at its N- and C-termini. To investigate the...

Truncated variants of hyaluronan-binding protein 1 bind hyaluronan and induce identical morphological aberrations in COS-1 cells.

Sengupta, Aniruddha, Tyagi, Rakesh K, Datta, Kasturi

Hyaluronan (HA)-binding protein 1 (HABP1) is multifunctional in nature and exists as a trimer through coiled-coil interaction between alpha-helices at its N- and C-termini. To investigate the...

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life

Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N

In silico and metabolic labeling studies of the selenoproteomes of several eukaryotes revealed distinct selenoprotein patterns as well as an ancient origin of selenoproteins and massive, independent...