Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Abstract Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This...
GOTax: investigating biological processes and biochemical activities along the taxonomic tree (2007)
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
Abstract We describe GOTax, a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins, protein families,...
GOTax: investigating biological processes and biochemical activities along the taxonomic tree (2007)
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
Abstract We describe GOTax, a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins, protein families,...
A new measure for functional similarity of gene products based on Gene Ontology (2006)
Schlicker, Andreas, Domingues, Francisco S, Rahnenführer, Jörg, Lengauer, Thomas
Abstract Background Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods that compare...
A new measure for functional similarity of gene products based on Gene Ontology
Schlicker, Andreas, Domingues, Francisco S, Rahnenführer, Jörg, Lengauer, Thomas
A new measure for functional similarity of gene products based on Gene Ontology
Schlicker, Andreas, Domingues, Francisco S, Rahnenführer, Jörg, Lengauer, Thomas
GOTax: investigating biological processes and biochemical activities along the taxonomic tree
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
GOTax, a novel web-based platform that integrates protein annotation with protein family classification and taxonomy, allows for an extensive assessment of functional similarity between proteins and...
The implications of alternative splicing in the ENCODE protein complement
Tress, Michael L., Martelli, Pier Luigi, Frankish, Adam, Reeves, Gabrielle A., Wesselink, Jan Jaap, Yeats, Corin, ...
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological...
FunSimMat: a comprehensive functional similarity database
Schlicker, Andreas, Albrecht, Mario
Functional similarity based on Gene Ontology (GO) annotation is used in diverse applications like gene clustering, gene expression data analysis, protein interaction prediction and evaluation....
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Structural analysis of the inhibitor Telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A shows that mutations at V36 and/or T54 result in impaired interaction with VX-950, explaining...