Genome-wide association study identifies novel breast cancer susceptibility loci (2007)
Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D.P., Thompson, Deborah, Ballinger, Dennis G., ...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast...
Genome-wide association study identifies novel breast cancer susceptibility loci (2007)
Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., ...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast...
Baynes, Caroline, Healey, Catherine S, Pooley, Karen A, Scollen, Serena, Luben, Robert N, Thompson, Deborah J, ...
Abstract Introduction Certain rare, familial mutations in the ATM , BRCA1 , BRCA2 , CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common...
Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk (2007)
Jonathan Tyrer, Alison M. Dunning, Douglas F. Easton
Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have been established. We have conducted...
Association between common variation in 120 candidate genes and breast cancer risk (2007)
Paul D. Pharoah, Jonathan Tyrer, Alison M. Dunning, Douglas F. Easton, Bruce A Ponder, SEARCH Study Team
Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles for breast cancer, but few definite associations have been established....
Stuart H. Ralston, André G. Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L. Langdahl, Paul Lips, ...
Stuart H. Ralston, André G. Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L. Langdahl, Paul Lips, ...
Stuart H. Ralston, André G. Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L. Langdahl, Paul Lips, ...
A large collaborative European study finds only weak links between a much studied potential genetic risk factor and bone mineral density or fracture risk.
Stuart H. Ralston, André G. Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L. Langdahl, Paul Lips, ...
Background Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work...
Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer (2005)
Peter Kraft, Paul Pharoah, Stephen J. Chanock, Demetrius Albanes, Laurence N. Kolonel, Richard B. Hayes, ...
Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due...
Benusiglio, Patrick R, Lesueur, Fabienne, Luccarini, Craig, Conroy, Donald M, Shah, Mitul, Easton, Douglas F, ...
Abstract Introduction About two-thirds of the excess familial risk associated with breast cancer is still unaccounted for and may be explained by multiple weakly predisposing alleles. A gene thought...
Atkinson, Charlotte, Warren, Ruth ML, Sala, Evis, Dowsett, Mitch, Dunning, Alison M, Healey, Catherine S, ...
Abstract Introduction Isoflavones are hypothesized to protect against breast cancer, but it is not clear whether they act as oestrogens or anti-oestrogens in breast tissue. Our aim was to determine...
Atkinson, Charlotte, Warren, Ruth ML, Sala, Evis, Dowsett, Mitch, Dunning, Alison M, Healey, Catherine S, ...
Benusiglio, Patrick R, Lesueur, Fabienne, Luccarini, Craig, Conroy, Donald M, Shah, Mitul, Easton, Douglas F, ...
The Extent of Linkage Disequilibrium in Four Populations with Distinct Demographic Histories
Dunning, Alison M., Durocher, Francine, Healey, Catherine S., Teare, M. Dawn, McBride, Simon E., Carlomagno, Francesca, ...
The design and feasibility of whole-genome–association studies are critically dependent on the extent of linkage disequilibrium (LD) between markers. Although there has been extensive theoretical...
Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer
Kraft, Peter, Pharoah, Paul, Chanock, Stephen J, Albanes, Demetrius, Kolonel, Laurence N, Hayes, Richard B, ...
Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due...
Ralston, Stuart H, Uitterlinden, André G, Brandi, Maria Luisa, Balcells, Susana, Langdahl, Bente L, Lips, Paul, ...
A large collaborative European study finds only weak links between a much studied potential genetic risk factor and bone mineral density or fracture risk.
Ralston, Stuart H, Uitterlinden, André G, Luisa Brandi, Maria, Balcells, Susana, Langdahl, Bente L, Lips, Paul, ...
Dunning, Alison M., Renges, Helmut-H., Xu, Chun-Fang, Peacock, Rachel, Brasseur, Robert, Laxer, Gerald, ...
We report the identification of an A-to-G base change, in exon 29 of the apolipoprotein B (apo B) gene, that results in the substitution of serine for asparagine at residue 4311 of mature apo B100....
Atkinson, Charlotte, Warren, Ruth ML, Sala, Evis, Dowsett, Mitch, Dunning, Alison M, Healey, Catherine S, ...
Benusiglio, Patrick R, Lesueur, Fabienne, Luccarini, Craig, Conroy, Donald M, Shah, Mitul, Easton, Douglas F, ...
The Extent of Linkage Disequilibrium in Four Populations with Distinct Demographic Histories
Dunning, Alison M., Durocher, Francine, Healey, Catherine S., Teare, M. Dawn, McBride, Simon E., Carlomagno, Francesca, ...
The design and feasibility of whole-genome–association studies are critically dependent on the extent of linkage disequilibrium (LD) between markers. Although there has been extensive theoretical...
Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer
Kraft, Peter, Pharoah, Paul, Chanock, Stephen J, Albanes, Demetrius, Kolonel, Laurence N, Hayes, Richard B, ...
Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due...
Ralston, Stuart H, Uitterlinden, André G, Brandi, Maria Luisa, Balcells, Susana, Langdahl, Bente L, Lips, Paul, ...
A large collaborative European study finds only weak links between a much studied potential genetic risk factor and bone mineral density or fracture risk.
Ralston, Stuart H, Uitterlinden, André G, Luisa Brandi, Maria, Balcells, Susana, Langdahl, Bente L, Lips, Paul, ...
Dunning, Alison M., Renges, Helmut-H., Xu, Chun-Fang, Peacock, Rachel, Brasseur, Robert, Laxer, Gerald, ...
We report the identification of an A-to-G base change, in exon 29 of the apolipoprotein B (apo B) gene, that results in the substitution of serine for asparagine at residue 4311 of mature apo B100....
Song, Honglin, Ramus, Susan J., Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A., Whittemore, Alice S., ...
Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk
Pharoah, Paul D. P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A. J
Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have been established. We have conducted...
Baynes, Caroline, Healey, Catherine S, Pooley, Karen A, Scollen, Serena, Luben, Robert N, Thompson, Deborah J, ...
Samuelson, David J., Hesselson, Stephanie E., Aperavich, Beth A., Zan, Yunhong, Haag, Jill D., Trentham-Dietz, Amy, ...
Breast cancer risk is a polygenic trait. To identify breast cancer modifier alleles that have a high population frequency and low penetrance we used a comparative genomics approach. Quantitative...