Ali Salim

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers (2006)

Jen-Tsan Chi, Zhen Wang, Edwin H. Rodriguez, Marci E. Schaner, Ali Salim, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers (2006)

Jen-Tsan Chi, Zhen Wang, Edwin H. Rodriguez, Marci E. Schaner, Ali Salim, ...

Background Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible...

Human BRCA1 inhibits growth in yeast: Potential use in diagnostic testing

Humphrey, Jeffrey S., Salim, Ali, Erdos, Michael R., Collins, Francis S., Brody, Lawrence C., Klausner, Richard D.

Germline-inactivating mutations of BRCA1 result in a hereditary predisposition to breast and ovarian cancer. Truncating mutations of BRCA1 predispose to cancer and can be ascertained by protein...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

The Effect of Trauma Center Designation and Trauma Volume on Outcome in Specific Severe Injuries

Demetriades, Demetrios, Martin, Mathew, Salim, Ali, Rhee, Peter, Brown, Carlos, Chan, Linda

American College of Surgeons designated level I trauma centers had significantly better survival and functional outcomes than level II centers. The volume of severe trauma admissions (15 per year)...

Genome-Wide Analysis of p53 under Hypoxic Conditions†

Hammond, Ester M., Mandell, Daniel J., Salim, Ali, Krieg, Adam J., Johnson, Thomas M., Shirazi, Haider A., ...

Hypoxia is an important nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progression. In this study, we investigated how genotoxic and nongenotoxic stresses...

Human BRCA1 inhibits growth in yeast: Potential use in diagnostic testing

Humphrey, Jeffrey S., Salim, Ali, Erdos, Michael R., Collins, Francis S., Brody, Lawrence C., Klausner, Richard D.

Germline-inactivating mutations of BRCA1 result in a hereditary predisposition to breast and ovarian cancer. Truncating mutations of BRCA1 predispose to cancer and can be ascertained by protein...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

The Effect of Trauma Center Designation and Trauma Volume on Outcome in Specific Severe Injuries

Demetriades, Demetrios, Martin, Mathew, Salim, Ali, Rhee, Peter, Brown, Carlos, Chan, Linda

American College of Surgeons designated level I trauma centers had significantly better survival and functional outcomes than level II centers. The volume of severe trauma admissions (15 per year)...

Genome-Wide Analysis of p53 under Hypoxic Conditions†

Hammond, Ester M., Mandell, Daniel J., Salim, Ali, Krieg, Adam J., Johnson, Thomas M., Shirazi, Haider A., ...

Hypoxia is an important nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progression. In this study, we investigated how genotoxic and nongenotoxic stresses...

Selective Nonoperative Management of Penetrating Abdominal Solid Organ Injuries

Demetriades, Demetrios, Hadjizacharia, Pantelis, Constantinou, Costas, Brown, Carlos, Inaba, Kenji, Rhee, Peter, ...

This is a prospective study of 152 patients with 185 penetrating solid organ injuries. Overall, 41 patients (27.0%), including 18 cases with grade III or V injuries, were successfully managed without...