Reduced reliance on the trace element selenium during evolution of mammals (2008)
Lobanov, Alexey V, Hatfield, Dolph L, Gladyshev, Vadim N
Abstract Background Selenium (Se) is an essential trace element that occurs in proteins in the form of selenocysteine (Sec). It is transported throughout the body in the form of Sec residues in...
Lobanov, Alexey V., Fomenko, Dmitri E., Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L., Gladyshev, Vadim N.
Background: Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and...
Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N
Abstract Background Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both...
Nosovelov, Sergey V., Lobanov, Alexey V., Hua, Deame, Kasaikina, Marina V., Hatfield, Dolph L., Gladyshev, Vadim
Selenoproteins are an elite group of proteins containing a rare amino acid, selenocysteine (Sec), encoded by the codon, UGA. In eukaryotes, incorporation of Sec requires a Sec insertion sequence...
Novoselov, Sergey V., Lobanov, Alexey V., Hua, Deame, Kasaikina, Marina V., Hatfield, Dolph L., Gladyshev, Vadim
Selenoproteins are an elite group of proteins containing a rare amino acid, selenocysteine (Sec), encoded by the codon, UGA. In eukaryotes, incorporation of Sec requires a Sec insertion sequence...
Mix, Heiko, Lobanov, Alexey V., Gladyshev, Vadim
Expression of selenocysteine (Sec)-containing proteins requires the presence of a cis-acting mRNA structure, called selenocysteine insertion sequence (SECIS) element. In bacteria, this structure is...
Lobanov, Alexey V., Gromer, Stephan, Salinas, Gustavo, Gladyshev, Vadim
Proteins containing the 21st amino acid selenocysteine (Sec) are present in the three domains of life. However, within lower eukaryotes, particularly parasitic protists, the dependence on the trace...
Mix, Heiko, Lobanov, Alexey V., Gladyshev, Vadim
Figure S1. Nucleotide sequence alignment of GPx4 sequences. For: M. musculus, H. sapiens, G. gallus, A. thaliana, Fowlpox virus, and Canarypox virus Figure S2. Alignment of GPx4 SECIS elements. For:...
Is there a twenty third amino acid in the genetic code? (2006)
Lobanov, Alexey V., Kryukov, Gregory V., Hatfield, Dolph L., Gladyshev, Vadim
The universal genetic code includes 20 common amino acids. In addition, selenocysteine (Sec) and pyrrolysine (Pyl), known as the twenty first and twenty second amino acids, are encoded by UGA and...
The Plasmodium selenoproteome (2006)
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Characterization of Mammalian Selenoproteomes (2003)
Kryukov, Gregory V., Castellano, Sergi, Novoselov, Sergey V., Lobanov, Alexey V., Zehtab, Omid, Guigo, Roderic, ...
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are...
Taskov, Kalin, Chapple, Charles, Kryukov, Gregory V., Castellano, Sergi, Lobanov, Alexey V., Korotkov, Konstantin V., ...
Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS) element. The number of selenoproteins...
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Castellano, Sergi, Lobanov, Alexey V., Chapple, Charles, Novoselov, Sergey V., Albrecht, Mario, Hua, Deame, ...
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has...
Lobanov, Alexey V., Gromer, Stephan, Salinas, Gustavo, Gladyshev, Vadim N.
Proteins containing the 21st amino acid selenocysteine (Sec) are present in the three domains of life. However, within lower eukaryotes, particularly parasitic protists, the dependence on the trace...
Taskov, Kalin, Chapple, Charles, Kryukov, Gregory V., Castellano, Sergi, Lobanov, Alexey V., Korotkov, Konstantin V., ...
Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS) element. The number of selenoproteins...
Castellano, Sergi, Lobanov, Alexey V., Chapple, Charles, Novoselov, Sergey V., Albrecht, Mario, Hua, Deame, ...
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has...
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Lobanov, Alexey V., Gromer, Stephan, Salinas, Gustavo, Gladyshev, Vadim N.
Proteins containing the 21st amino acid selenocysteine (Sec) are present in the three domains of life. However, within lower eukaryotes, particularly parasitic protists, the dependence on the trace...
Mix, Heiko, Lobanov, Alexey V., Gladyshev, Vadim N.
Expression of selenocysteine (Sec)-containing proteins requires the presence of a cis-acting mRNA structure, called selenocysteine insertion sequence (SECIS) element. In bacteria, this structure is...
Novoselov, Sergey V., Lobanov, Alexey V., Hua, Deame, Kasaikina, Marina V., Hatfield, Dolph L., Gladyshev, Vadim N.
Selenoproteins are an elite group of proteins containing a rare amino acid, selenocysteine (Sec), encoded by the codon, UGA. In eukaryotes, incorporation of Sec requires a Sec insertion sequence...
Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N
In silico and metabolic labeling studies of the selenoproteomes of several eukaryotes revealed distinct selenoprotein patterns as well as an ancient origin of selenoproteins and massive, independent...
Reduced reliance on the trace element selenium during evolution of mammals
Lobanov, Alexey V, Hatfield, Dolph L, Gladyshev, Vadim N
Evolution from fish to mammals was accompanied by decreased use of selenocysteine, raising questions about the need for selenium dietary supplements when pathology is not imminent.