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Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

Kleemann, Robert,
Verschuren, Lars,
Van Erk, Marjan J,
Nikolsky, Yuri,
Cnubben, Nicole HP,
Verheij, Elwin R,
Smilde, Age K,
Hendriks, Henk FJ,
Zadelaar, Susanne,
Smith, Graham J,
Kaznacheev, Valery,
Nikolskaya, Tatiana,
Melnikov, Anton,
Hurt-Camejo, Eva,
Van Der Greef, Jan,
Van Ommen, Ben,
Kooistra, Teake

Abstract

With increasing dietary cholesterol intake the liver switches from a mainly resilient to a predominantly inflammatory state, which is associated with early lesion formation.

Publication details

Download	http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2375038
Publisher	BioMed Central
Repository	PubMed Central (PMC3 - NLM DTD) (United States)
Keywords	Research
Type	Text
Language	English