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Partial characterization of Ia antigens from murine lymphoid cells (1974)

Abstract

Congenic anti-Ia antisera were used to bind radiolabelled Ia antigens from cells of various strains of mice of known H-2 haplotype. The results indicate that Ia antigens are proteins of molecular weight 30,000 to 35,000 daltons. The Ia antigens are distinct from known H-2 antigens as judged by independent immunoprecipitation as well as by molecular weight. Ia antigens are synthesized by, and are present on the surface of lymphoid cells as evidenced by incorporation studies using 3 H-leucine and enzymatic radioiodination of cells, respectively. Tissue distribution of cell surface Ia suggests that Ia antigens are on B cells. Ia antigens were detected in the incubation media of 3 H-leucine labeled splenocytes suggesting that antigens may be secreted.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/46728/1/251_2005_Article_BF01564048.pdf

Publication details

Download	, http://hdl.handle.net/2027.42/46728
Publisher	Springer-Verlag; Springer-Verlag New York Inc.
Contributors	Department of Microbiology, University of Texas, Southwestern Medical School, 75235, Dallas, Texas; Irvington House Institute and Department of Microbiology, N.Y.U. School of Medicine, 10016, New York, N.Y.; Departments of Human Genetics and Oral Biology, Schools of Dentistry and Medicine, University of Michigan, 48104, Ann Arbor, Michigan, Department of Microbiology, University of Texas, Southwestern Medical School, 75235, Dallas, Texas; Irvington House Institute and Department of Microbiology, N.Y.U. School of Medicine, 10016, New York, N.Y.; Departments of Human Genetics and Oral Biology, Schools of Dentistry and Medicine, University of Michigan, 48104, Ann Arbor, Michigan, Department of Microbiology, University of Texas, Southwestern Medical School, 75235, Dallas, Texas; Irvington House Institute and Department of Microbiology, N.Y.U. School of Medicine, 10016, New York, N.Y.; Departments of Human Genetics and Oral Biology, Schools of Dentistry and Medicine, University of Michigan, 48104, Ann Arbor, Michigan, Ann Arbor
Repository	University of Michigan (United States)
Keywords	Cell Biology, Biomedicine, Immunology, Allergology, Public Health, Biological Chemistry, Science, Health Sciences
Language	English

Cited publications (1)

Biology of the mouse histocompatibility-2 complex

Kennett, Roger H.