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Evidence for a third, Ir -associated histocompatibility region in the H-2 complex of the mouse (1974)

Abstract

Skin grafts transplanted from B10.HTT donors onto (A.TL × B10)F 1 recipients are rapidly rejected despite the fact that the B10.HTT and A.TL strains should be carrying the same H-2 chromosomes and that both the donor and the recipient contain the B10 genome. The rejection is accompanied by a production of cytotoxic antibodies against antigens controlled by the Ir region of the H-2 complex. These unexpected findings are interpreted as evidence for a third histocompatibility locus in the H-2 complex, H-2I , located in the Ir region close to H-2K . The B10.HTT and A.TL strains are postulated to differ at this hypothetical locus, and the difference between the two strains is explained as resulting from a crossing over between the H-2 t1 and H-2 s chromosomes in the early history of the B10.HTT strain. The H-2 genotypes of the B10.HTT and A.TL strains are assumed to be H-2K s Ir s / k Ss k H-2D d and H-2K s Ir k Ss k H-2D d , respectively. Thus, the H-2 chromosomes of the two strains differ only in a portion of the Ir region, including the H-2I locus. The B10.HTT( H-2 tt ) and B10.S(7R)( H-2 th ) strains differ in a relatively minor histocompatibility locus, possibly residing in the Tla region outside of the H-2 complex.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/46727/1/251_2005_Article_BF01564045.pdf

Publication details

Download	, http://hdl.handle.net/2027.42/46727
Publisher	Springer-Verlag; Springer-Verlag New York Inc.
Contributors	Department of Human Genetics, Medical School, The University of Michigan, 48104, Ann Arbor, Michigan, Department of Oral Biology, School of Dentistry, The University of Michigan, 48104, Ann Arbor, Michigan; Department of Human Genetics, Medical School, The University of Michigan, 48104, Ann Arbor, Michigan, Department of Human Genetics, Medical School, The University of Michigan, 48104, Ann Arbor, Michigan, Ann Arbor
Repository	University of Michigan (United States)
Keywords	Allergology, Biomedicine, Cell Biology, Immunology, Public Health, Biological Chemistry, Science, Health Sciences
Language	English

Cited publications (1)

Symposium on in vitro studies of the immune response. I. Variations in the immune response to a simple determinant.