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Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan,
Wang, Zhen,
Nuyten, Dimitry S. A,
Rodriguez, Edwin H,
Schaner, Marci E,
Salim, Ali,
Wang, Yun,
Kristensen, Gunnar B,
Helland, Åslaug,
Børresen-Dale, Anne-Lise,
Giaccia, Amato,
Longaker, Michael T,
Hastie, Trevor,
Yang, George P,
Van De Vijver, Marc J,
Brown, Patrick O

Abstract

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and ovarian cancer.

Publication details

Download	http://www.pubmedcentral.gov/articlerender.fcgi?artid=1334226
Publisher	Public Library of Science
Repository	PubMed Central (PMC3 - NLM DTD) (United States)
Keywords	Research Article
Type	Text
Language	Englisch