Recently added Publications
Hoe gaan artsen en verpleegkundigen om met wrijvingen in hun samenwerking? (2010)
Abstract In health care, optimal collaboration between nurses and physicians is crucial in the quality of the care process - but not self-generating. Little is known about how health-care...
An optical study of single pentacene molecules in n-tetradecane (2000)
Durand, Yannig,, Bloeß, Andreas,, Oijen, Antoine M. Van,, Köhler, Jürgen,, Groenen, Edgar J.J.,, Schmidt, Jan,
We report the spectroscopic observation of single pentacene molecules in the matrices n-tetradecane and n-hexadecane, using a confocal microscope operating at liquid-helium temperatures. A maximum...
Oijen, A.M. Van,, Ketelaars, M.,, Köhler, J.,, Aartsma, T.J.,, Schmidt, J.,
This paper reports a detailed spectroscopic study of the B800 absorption band of individual light-harvesting 2 (LH2) complexes of the photosynthetic purple bacterium Rhodopseudomonas acidophila at...
Matsushita, M.,, Ketelaars, M.,, Oijen, A.M. Van,, Köhler, J.,, Aartsma, T.J.,, Schmidt, J.,
Spectroscopy of individual light-harvesting 2 complexes from purple photosynthetic bacteria revealed a deformation of the circular complex into C2 symmetry. The present work relates the geometry of...
Ketelaars, M.,, Oijen, A.M. Van,, Matsushita, M.,, Köhler, J.,, Schmidt, J.,, Aartsma, T.J.,
The electronic structure of the circular aggregate of 18 bacteriochlorophyll a (BChl a) molecules responsible for the B850 absorption band of the light-harvesting 2 (LH2) complex of the...
Continuous-wave two-photon excitation of individual CdS nanocrystallites (2001)
Oijen, A.M. Van,, Verberk, R.,, Durand, Y.,, Schmidt, J.,, Lingen, J.N.J. Van,, Bol, A.A.,, ...
By use of low-temperature confocal microscopy, continuous-wave two-photon fluorescence images are obtained of individual CdS nanocrystallites embedded in a polymer matrix. The quadratic dependence of...
Simple model for the power-law blinking of single semiconductor nanocrystals (2002)
Verberk, Rogier,, Oijen, Antoine M. Van,, Orrit, Michel,
We assign the blinking of nanocrystals to electron tunneling towards a uniform spatial distribution of traps. This naturally explains the power-law distribution of off times, and the power-law...
Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder (2003)
Oijen, Antoine M. Van,, Blainey, Paul C.,, Crampton, Donald J.,, Richardson, Charles C.,, Ellenberger, Tom,, Xie, X. Sunney,
We used a multiplexed approach based on flow-stretched DNA to monitor the enzymatic digestion of λ-phage DNA by individual bacteriophage λ exonuclease molecules. Statistical analyses of multiple...
Endocytosis by Random Initiation and Stabilization of Clathrin-Coated Pits (2004)
Ehrlich, Marcelo,, Boll, Werner,, Oijen, Antoine Van,, Hariharan, Ramesh,, Chandran, Kartik,, Nibert, Max L.,, ...
Clathrin-coated vesicles carry traffic from the plasma membrane to endosomes. We report here the real-time visualization of cargo sorting and endocytosis by clathrin-coated pits in living cells. We...
Doping kinetics of organic semiconductors investigated by field-effect transistors (2010)
Maddalena, F.,, Meijer, E.J.,, Asadi, K.,, Leeuw, D.M. De,, Blom, P.W.M.,
The kinetics of acid doping of the semiconductor regioregular poly-3-hexylthiophene with vaporized chlorosilane have been investigated using field-effect transistors. The dopant density has been...
Blainey, Paul C.,, Oijen, Antoine M. Van,, Banerjee, Anirban,, Verdine, Gregory L.,, Xie, X. Sunney,
A central mystery in the function of site-specific DNA-binding proteins is the detailed mechanism for rapid location and binding of target sites in DNA. Human oxoguanine DNA glycosylase 1 (hOgg1),...
DNA primase acts as a molecular brake in DNA replication (2006)
Lee, Jong-Bong,, Hite, Richard K.,, Hamdan, Samir M.,, Xie, X. Sunney,, Richardson, Charles C.,, Oijen, Antoine M. Van,
A hallmark feature of DNA replication is the coordination between the continuous polymerization of nucleotides on the leading strand and the discontinuous synthesis of DNA on the lagging strand. This...
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited (2006)
English, Brian P.,, Min, Wei,, Oijen, Antoine M. Van,, Lee, Kang Taek,, Luo, Guobin,, Sun, Hongye,, ...
Enzymes are biological catalysts vital to life processes and have attracted century-long investigation. The classic Michaelis-Menten mechanism provides a highly satisfactory description of catalytic...
Dynamic DNA Helicase-DNA Polymerase Interactions Assure Processive Replication Fork Movement (2007)
Hamdan, Samir M.,, Johnson, Donald E.,, Tanner, Nathan A.,, Lee, Jong-Bong,, Qimron, Udi,, Tabor, Stanley,, ...
A single copy of bacteriophage T7 DNA polymerase and DNA helicase advance the replication fork with a processivity greater than 17,000 nucleotides. Nonetheless, the polymerase transiently dissociates...
Single-molecule studies of complex systems: the replisome (2007)
Oijen, Antoine M. Van,
A complete, system-level understanding of biological processes requires comprehensive information on the kinetics and thermodynamics of the underlying biochemical reactions. A wide variety of...
Honey, I Shrunk the DNA: DNA Length as a Probe for Nucleic-Acid Enzyme Activity (2007)
Oijen, Antoine M. Van,
The replication, recombination, and repair of DNA are processes essential for the maintenance of genomic information and require the activity of numerous enzymes that catalyze the polymerization or...
Fujiyoshi, Satoru,, Fujiwara, Masanori,, Kim, Changman,, Matsushita, Michio,, Oijen, Antoine M. Van,, Schmidt, Jan,
A single-component reflecting objective was constructed for low-temperature spectroscopy with optimal imaging and transmission properties at all visible wavelengths. The performance of the objective...
Sustainability analysis of agave production in Mexico (2010)
Worldwide food production is done in different types of agricultural production systems. The main difference is whether it is an intensive or extensive system. The agave production in Mexico has been...
Exposure to natural radioactivity in the Netherlands: the impact of building materials (2010)
Jong, Peter De,
Samenvatting Een belangrijk deel van de natuurlijke stralingsbelasting die de Nederlander ontvangt, is het gevolg van verblijf in woningen. Deze stralingsbelasting wordt teweeggebracht door de...
Enviromental signals affecting ica-expression in Staphylococcus epidermidis (2010)
Nuryastuti, Titik,
Abstract Staphylococcus epidermidis is a nosocomial pathogen, associated with infections of indwelling medical devices. The ability to adhere and form biofilms on biomaterial surfaces contributes to...
Advanced methods for prototype-based classification (2010)
Schneider, Petra,
The thesis presents different concepts to improve the performance of LVQ algorithms. One issue refers to metric learning in LVQ, i.e., the optimization of the employed distance measure for a specific...
Artificial cofactors: a marriage of homogeneous catalysis with enzymology (2010)
Jin, Jianfeng,
In the evolution of enzymes, cofactors have been incorporated into enzymes to provide diverse activities. The introduction of artificial cofactors, which can alter the activity and selectivity of...
Kale, Avinash,
Chapter 1 presents a short review on leucine aminopeptidases. These are zinc-dependent proteases are widespread and occur in all kingdoms of life. Generally, they take care of protein degradation and...
An Evaluation of a Victim Offender Mediation Program at a Juvenile Court (2010)
This research project evaluates a Victim Offender Mediation (VOM) program established by a Juvenile Court in Northeast Ohio. The research focuses on the procedure used in the program, the driving...
After March 14 Tibet Riots: A New Wave of Chinese Nationalism (2010)
The thesis is a case study of the Chinese nationalist movements after the Tibet riots in 2008. It is a qualitative research study. I use critical theory to analyze the stimulus of the movement, the...
COMMERCIALIZATION OF STEM CELL THERAPY FOR THE TREATMENT OF DIABETIC RETINOPATHY (2010)
Diabetic Retinopathy is one of the leading causes of blindness or vision loss in working-age adults. Millions of adults over age forty are affected by the diseases and there exists an impending need...
Transitioning to E-Portfolios in a First-Year Writing Program (2010)
Building off the scholarship of paper-based portfolio systems, electronic portfolios have been a topic of scholarly conversation across the university, particularly in writing studies, education, and...
Turandot's Homecoming: Seeking the Authentic Princess of China in a New Contest of Riddles (2010)
The negative portrait of Chinese culture in Puccini's Turandot hindered this opera's acceptance in China. Wei Minglun's Sichuan Opera performance Chinese Princess Turandot (1995) and Zhang Yimou's...
Barney, Jason Phillip, 1975-
Indiana University-Purdue University Indianapolis (IUPUI)
Ohtsuki, Takashi, Yamamoto, Hiromichi, Doi, Yoshio, Sisido, Masahiko
We present three methods relating to tRNA aminoacylation with non-natural amino acids using an Escherichia coli EF-Tu E215A/D216A mutant that can bind tightly to aa-tRNAs carrying either non-natural...
Liu, Xiaolei, Luo, Qian, Zhong, Guohua, Rizwan-ul-Haq, Muhammad, Hu, Meiying
Some chemosensory proteins (CSPs) expressed in insect sensory appendages are thought to be involved in chemical signaling in moths. We cloned and characterized four CSP genes from Plutella...
Site-specific incorporation of 4-Iodo-L-phenylalanine through opal suppression (2010)
Kodama, Koichiro, Nakayama, Hiroshi, Sakamoto, Kensaku, Fukuzawa, Seketsu, Kigawa, Takanori, Yabuki, Takashi, ...
A variety of unique codons have been employed to expand the genetic code. The use of the opal (UGA) codon is promising, but insufficient information is available about the UGA suppression approach,...
Van Walderveen, Maria C., Berry, Leslie R., Chan, Anthony K.C.
Protein C in its activated form (APC) limits thrombin generation. Protein C inhibitor (PCI) readily neutralizes APC. Heparin accelerates this reaction, which may complicate anticoagulant treatment in...
Hsu, Chun-Hua, Pan, Yun-Ru, Liao, You-Di, Wu, Shih-Hsiung, Chen, Chinpan
The stability, structures and steric hindrances of recombinant RNases 2 and 4 expressed in bacteria were studied by circular dichroism (CD) and NMR techniques, and the results were compared with...
Badoei-Dalfard, Arastoo, Khajeh, Khosro, Asghari, S. Mohsen, Ranjbar, Bijan, Karbalaei-Heidari, Hamid Reza
Salinivibrio zinc-metalloprotease (SVP) is an enzyme which was isolated from Salinivibrio proteolyticus, a moderately halophilic species from a hypersaline lake in Iran. A195E and G203D mutants were...
Liu, Xiaohui, Matsushima, Ayami, Okada, Hiroyuki, Shimohigashi, Yasuyuki
Bisphenol A (BPA) strongly binds to human estrogen-related receptor γ (ERRγ). BPA is an oestrogenic endocrine disruptor that influences various physiological functions at very low doses. BPA...
Shibata, Tomokazu, Nagao, Satoshi, Tai, Hulin, Nagatomo, Shigenori, Hamada, Hiromi, Yoshikawa, Hiroyuki, ...
Human adult haemoglobin (Hb A), a tetrameric oxygen transfer haemoprotein, has been recognized as an excellent model for investigating the structure–function relationships in allosteric proteins,...
Kurosawa, Kohei, Lin, Waka, Ohta, Kunihiro
The class I histone deacetylases HDAC1 and HDAC2 are highly conserved except for their C-terminal domain, but are presumed to have distinct functions in various tissues. We investigated the division...
Identification and characterization of the promoter of human ATF5 gene (2010)
Wei, Yuanyan, Ge, Yuqing, Zhou, Fengbiao, Chen, Hong, Cui, Chunhong, Liu, Dan, ...
ATF5, a member of ATF/CREB family of b-ZIP transcription factors, is highly expressed in a wide variety of neoplasms and regulates cell differentiation, cell survival and apoptosis. However, the...
Screening of cell death genes with a mammalian genome-wide RNAi library (2010)
Tsujii, Hisayo, Eguchi, Yutaka, Chenchik, Alex, Mizutani, Takayuki, Yamada, Kayoko, Tsujimoto, Yoshihide
We report the construction and application of a mammalian genome-wide RNAi library. The oligodeoxynucleotides encoding ∼200,000 shRNA sequences that targeted 47,400 human transcripts were inserted...
A Cys/Ser mutation of NDPK-A stabilizes its oligomerization state and enhances its activity (2010)
Chen, Yunru, Qian, Chuiwen, Guo, Chaowan, Ge, Feng, Zhang, Xiaowei, Gao, Xue, ...
Nucleoside diphosphate phosphate transferase A (NDPK-A) has been shown to play critical roles in the regulation of proliferation, differentiation, growth and apoptosis of cells. Our previous study...
Takeda, Kazuhisa, Takahashi, Na-Ho, Yoshizawa, Miki, Shibahara, Shigeki
Lipocalin-type prostaglandin D synthase (L-PGDS) catalyses the formation of prostaglandin D2 (PGD2) and also functions as a transporter for lipophilic ligands, including all-trans retinoic acid (RA)....
Yasutomi Nishizuka: Father of protein kinase C (2010)
Nakamura, Shun-ichi, Yamamura, Hirohei
It is 6 years since we received the tragic news that our great mentor Dr Yasutomi Nishizuka passed away suddenly at the age of 72 years. Dr Nishizuka made several epoch-making discoveries in his...
CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone (2010)
Hida, Yamato, Ohtsuka, Toshihisa
Cytomatrix at the active zone-associated structural protein (CAST) was first purified from rat brain. It belongs to a protein family with the protein ELKS being its close relative. In nerve...
The British Fight against Cancer: Publicity and Education, 1900-1948 (2010)
This article explores the early history of cancer education in Britain, focusing on the period between 1900, when discussions about a public ‘crusade’ against cancer began in Britain, and the...
With Chinese efforts to modernise medicine at the turn of the twentieth century, many intellectuals feared the loss of cultural integrity that would ensue, as modern medicine was tied to the very...
'Growing Babies': Defining the Milk Requirements of Infants 1890-1910 (2010)
How babies should best be fed was a pressing question at a time when infant mortality in many parts of Europe and North America was well above 100 per 1,000 live births, and recognised to be strongly...
A Century of Cardiomythology: Exercise and the Heart c.1880-1980 (2010)
The relationship between health and exercise involves risks as well as rewards. This article focuses on heart disease and the marathon to show how doctors have negotiated that relationship over a...
Sports medicine has been largely neglected by historians. This article examines the development of the role of the football trainer from 1885 to 1992, placing it in the wider context of the shifting...
This article examines the impact of the 1889–93 ‘Russian’ influenza on late Victorian society and culture. Using medical officer of health and national and local newspaper reports, and the...